Posters & Presentations
ELAINE – 1
Durable Complete Remission of Metastatic ER+/HER2− Breast Cancer after Lasofoxifene Therapy
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Dr. Gal-Yam’s presentation from MBCRC 2022
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Vaginal and Vulvar Symptoms in Patients with ESR1-Mutated, ER+/HER2- Metastatic Breast Cancer by Baseline Characteristics
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Open-label, randomized study of lasofoxifene (LAS) vs fulvestrant (Fulv) for women with locally advanced/metastatic ER+/HER2- breast cancer (mBC), an estrogen receptor 1 (ESR1) mutation, and disease progression on aromatase (AI) and cyclin-dependent kinase 4/6 (CDK4/6i) inhibitors
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Vaginal/Vulvar Symptoms with Lasofoxifene Versus Fulvestrant in ESR1-Mutated, ER+/HER2- Metastatic Breast Cancer Patients
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Estrogen receptor 1 (ESR1) mutations in circulating tumor DNA (ctDNA) from patients with ER+/HER2- metastatic breast cancer (mBC) treated with lasofoxifene or fulvestrant in the ELAINE 1 study
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Lasofoxifene Reduced ESR1 Mutant Allele Fraction and Provided Clinical Benefit versus Fulvestrant in Metastatic Breast Cancer: the ELAINE 1 trial
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Open-label, randomized study of lasofoxifene (LAS) vs fulvestrant (Fulv) for women with locally advanced/metastatic ER+/HER2- breast cancer (mBC), an estrogen receptor 1 (ESR1) mutation, and disease progression on aromatase (AI) and cyclin-dependent kinase 4/6 (CDK4/6i) inhibitors
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ELAINE – 2
SABCS ELAINE 2 Genomics poster
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SABCS Lasofoxifene PK poster
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Lasofoxifene (LAS) Plus Abemaciclib (Abema) for Treating ESR1-mutated ER+/HER2- Metastatic Breast Cancer (mBC) after Progression on Prior Therapies: ELAINE 2 Study Update
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Lasofoxifene (LAS) Plus Abemaciclib (Abema) for Treating ESR1-mutated ER+/HER2- Metastatic Breast Cancer (mBC) after Progression on Prior Therapies: ELAINE 2 Study Update
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Open-Label, Phase 2, Multicenter Study of Lasofoxifene (LAS) Combined with Abemaciclib (Abema) for Treating Pre- and Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2− Breast Cancer and an ESR1 Mutation After Progression on Prior Therapies
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Open-Label, Phase 2, Multicenter Study of Lasofoxifene (LAS) Combined with Abemaciclib (Abema) for Treating Pre- and Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2− Breast Cancer and an ESR1 Mutation After Progression on Prior Therapies
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An Open-label, Randomized, Multi-center Phase 2 Study Evaluating the Activity of Lasofoxifene Relative to Fulvestrant for the Treatment of Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2- Breast Cancer with an ESR1 Mutation
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ELAINE – 3
SABCS ELAINE 3 TiP poster
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Phase 3 Study of Lasofoxifene Plus Abemaciclib to Treat ER+/HER2-, ESR1-Mutated, Metastatic Breast Cancer
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EQUALS
EQUALS: Vaginal/Sexual Health (VSH) in Patients with ER+/HER2- Metastatic Breast Cancer (mBC)
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QUALITY OF LIFE
SABCS EQUALS 3 Communications poster
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SABCS EQUALS 3 Toxicity poster
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Vaginal and Sexual Health in Patients with ER+/HER2- Metastatic Breast Cancer (mBC)
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Knowledge of Tumor/Blood Genomic Testing (NGS) and ESR1 Mutations in a Survey of Patients with ER+/HER2- Metastatic Breast Cancer (mBC)
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Physician Perceptions of Estrogen Agonist/Antagonists in Menopausal Health: A Survey to Address Osteoporosis, Urogenital Health and Breast Concerns in Menopause and Breast Cancer Survivorship
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Patient Knowledge, Attitudes and Perceptions Regarding Breast Cancer Biomarkers, Testing, and Quality of Life
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A Preliminary Assessment of Knowledge, Attitudes, and Awareness Surrounding Precision Medicine, ESR1 Mutations, and Biomarker Testing Amongst Medical Oncologists
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Lasofoxifene, an Estrogen Agonist/Antagonist, Improves Symptoms of Genitourinary Syndrome and Menopause (GSM) and Physiologic Markers Associated with Vulvovaginal Atrophy (VVA) in Two Large Phase 3 Studies
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PRECLINICAL
Lasofoxifene alone or in combination with palbociclib is an effective treatment for therapy-resistant ER-positive metastatic breast cancer
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Lasofoxifene as a Potential Treatment for Aromatase Inhibitor Resistant ER+ Breast Cancer
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Lasofoxifene Decreases Breast Cancer Lung and Liver Metastasis in a Mammary Intraductal (MIND) Xenograft Model of Mutant ERa+ Breast Cancer
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Lasofoxifene 0.25 mg Compared with Raloxifene 60 mg for Effects on Bone Mineral Density and Markers of Bone Turnover: Results from the Phase 3 Comparison of Raloxifene and Lasofoxifene (CORAL) Trial
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ADDITIONAL STUDIES
(Trial in Progress) A phase 2, open-label, randomized multicenter trial to evaluate neoadjuvant lasofoxifene in molecularly-selected HR+/HER2- Clinical Stage 2/3 breast cancer
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I-SPY2 Endocrine Optimization Pilot (EOP): Neoadjuvant Lasofoxifene in Molecularly Selected Patients with hormone receptor positive (HR+)/HER2 negative (HER2-) Stage 2/3 Breast Cancer
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