Posters & Presentations

ELAINE – 1

Durable Complete Remission of Metastatic ER+/HER2− Breast Cancer after Lasofoxifene Therapy

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Dr. Gal-Yam’s presentation from MBCRC 2022

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Vaginal and Vulvar Symptoms in Patients with ESR1-Mutated, ER+/HER2- Metastatic Breast Cancer by Baseline Characteristics

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Open-label, randomized study of lasofoxifene (LAS) vs fulvestrant (Fulv) for women with locally advanced/metastatic ER+/HER2- breast cancer (mBC), an estrogen receptor 1 (ESR1) mutation, and disease progression on aromatase (AI) and cyclin-dependent kinase 4/6 (CDK4/6i) inhibitors

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Vaginal/Vulvar Symptoms with Lasofoxifene Versus Fulvestrant in ESR1-Mutated, ER+/HER2- Metastatic Breast Cancer Patients

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Estrogen receptor 1 (ESR1) mutations in circulating tumor DNA (ctDNA) from patients with ER+/HER2- metastatic breast cancer (mBC) treated with lasofoxifene or fulvestrant in the ELAINE 1 study

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Lasofoxifene Reduced ESR1 Mutant Allele Fraction and Provided Clinical Benefit versus Fulvestrant in Metastatic Breast Cancer: the ELAINE 1 trial

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Open-label, randomized study of lasofoxifene (LAS) vs fulvestrant (Fulv) for women with locally advanced/metastatic ER+/HER2- breast cancer (mBC), an estrogen receptor 1 (ESR1) mutation, and disease progression on aromatase (AI) and cyclin-dependent kinase 4/6 (CDK4/6i) inhibitors

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ELAINE – 2

SABCS ELAINE 2 Genomics poster

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SABCS Lasofoxifene PK poster

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Lasofoxifene (LAS) Plus Abemaciclib (Abema) for Treating ESR1-mutated ER+/HER2- Metastatic Breast Cancer (mBC) after Progression on Prior Therapies: ELAINE 2 Study Update

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Lasofoxifene (LAS) Plus Abemaciclib (Abema) for Treating ESR1-mutated ER+/HER2- Metastatic Breast Cancer (mBC) after Progression on Prior Therapies: ELAINE 2 Study Update

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Open-Label, Phase 2, Multicenter Study of Lasofoxifene (LAS) Combined with Abemaciclib (Abema) for Treating Pre- and Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2− Breast Cancer and an ESR1 Mutation After Progression on Prior Therapies

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Open-Label, Phase 2, Multicenter Study of Lasofoxifene (LAS) Combined with Abemaciclib (Abema) for Treating Pre- and Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2− Breast Cancer and an ESR1 Mutation After Progression on Prior Therapies

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An Open-label, Randomized, Multi-center Phase 2 Study Evaluating the Activity of Lasofoxifene Relative to Fulvestrant for the Treatment of Postmenopausal Women with Locally Advanced or Metastatic ER+/HER2- Breast Cancer with an ESR1 Mutation

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ELAINE – 3

SABCS ELAINE 3 TiP poster

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QUALITY OF LIFE

SABCS EQUALS 3 Communications poster

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SABCS EQUALS 3 Toxicity poster

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Vaginal and Sexual Health in Patients with ER+/HER2- Metastatic Breast Cancer (mBC)

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Knowledge of Tumor/Blood Genomic Testing (NGS) and ESR1 Mutations in a Survey of Patients with ER+/HER2- Metastatic Breast Cancer (mBC)

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Physician Perceptions of Estrogen Agonist/Antagonists in Menopausal Health: A Survey to Address Osteoporosis, Urogenital Health and Breast Concerns in Menopause and Breast Cancer Survivorship

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Patient Knowledge, Attitudes and Perceptions Regarding Breast Cancer Biomarkers, Testing, and Quality of Life

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A Preliminary Assessment of Knowledge, Attitudes, and Awareness Surrounding Precision Medicine, ESR1 Mutations, and Biomarker Testing Amongst Medical Oncologists

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Lasofoxifene, an Estrogen Agonist/Antagonist, Improves Symptoms of Genitourinary Syndrome and Menopause (GSM) and Physiologic Markers Associated with Vulvovaginal Atrophy (VVA) in Two Large Phase 3 Studies

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PRECLINICAL

Lasofoxifene alone or in combination with palbociclib is an effective treatment for therapy-resistant ER-positive metastatic breast cancer

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Lasofoxifene as a Potential Treatment for Aromatase Inhibitor Resistant ER+ Breast Cancer

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Lasofoxifene Decreases Breast Cancer Lung and Liver Metastasis in a Mammary Intraductal (MIND) Xenograft Model of Mutant ERa+ Breast Cancer

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Lasofoxifene 0.25 mg Compared with Raloxifene 60 mg for Effects on Bone Mineral Density and Markers of Bone Turnover: Results from the Phase 3 Comparison of Raloxifene and Lasofoxifene (CORAL) Trial

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ADDITIONAL STUDIES

(Trial in Progress) A phase 2, open-label, randomized multicenter trial to evaluate neoadjuvant lasofoxifene in molecularly-selected HR+/HER2- Clinical Stage 2/3 breast cancer

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